Friday, October 12, 2012

CDC: Meningitis cases reach 170, 14 people die

(AP) ? The government says 170 people now have been sickened in the meningitis outbreak linked to tainted steroid shots, and 14 of them have died.

Idaho becomes the 11th state to report at least one illness. The others are Florida, Indiana, Maryland, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Tennessee and Virginia.

The Centers for Disease Control and Prevention updated the count Thursday, showing 33 more cases and two additional deaths reported to the agency in the past day. The outbreak of rare fungal meningitis has been linked to steroid shots for back pain. A specialty pharmacy in Massachusetts has recalled the steroid that was sent to clinics in 23 states, as well as everything else it makes.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-10-11-Meningitis%20Outbreak/id-6c438421d7be4d8a99774f163c5481d2

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Thursday, October 11, 2012

Romney Tops Obama Ad Spending (WSJ)

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Gene implicated in schizophrenia risk is also associated with risk for cannabis dependence

ScienceDaily (Oct. 11, 2012) ? A paper by Shizhong Han and colleagues in the current issue of Biological Psychiatry implicates a new gene in the risk for cannabis dependence. This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.

The researchers set out to investigate susceptibility genes for cannabis dependence, as research has already shown that it has a strong genetic component.

To do this, they employed a multi-stage design using genetic data from African American and European American families. In the first stage, a linkage analysis, the strongest signal was identified in African Americans on chromosome 8p21. Then using a genome-wide association study dataset, they identified one genetic variant at NRG1 that showed consistent evidence for association in both African Americans and European Americans. Finally, they replicated the association of that same variant in an independent sample of African-Americans.

All together, the findings suggest that NRG1 may be a susceptibility gene for cannabis dependence.

An interesting feature of this paper is that these findings may also suggest a link between the genetics of schizophrenia and the genetics of cannabis dependence. NRG1 emerged into public awareness after a series of genetic studies implicated it in the heritable risk for schizophrenia. Subsequent studies in post-mortem brain tissue also suggested that the regulation of NRG1 was altered in the brains of individuals diagnosed with schizophrenia.

Thus, the current findings may help to explain the already established link between cannabis use and the risk for developing schizophrenia. A number of epidemiologic studies have attributed the association of cannabis use and schizophrenia to the effects of cannabis on the brain rather than a common genetic link between these two conditions.

"The current data provide a potentially important insight into the heritable risk for schizophrenia and raise the possibility that there are some common genetic contributions to these two disorders," commented Dr. John Krystal, Editor of Biological Psychiatry.

However, further research will be necessary to further confirm the role that NRG1 plays in cannabis dependence and the potential link between cannabis use and psychosis.

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The above story is reprinted from materials provided by Elsevier, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Shizhong Han, Bao-Zhu Yang, Henry R. Kranzler, David Oslin, Raymond Anton, Lindsay A. Farrer, Joel Gelernter. Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans. Biological Psychiatry, 2012; 72 (8): 637 DOI: 10.1016/j.biopsych.2012.02.038

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/lwfoZBou_aM/121011085342.htm

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Nikkei hits two-month low on corporate earnings concerns

TOKYO (Reuters) - Japan's Nikkei average fell to a two-month low on Wednesday on concerns that upcoming corporate earnings for the latest quarter would be hurt by sluggish global growth, as the IMF cut its forecasts for the second time since April.

SmartEstimates from Thomson Reuters StarMine expects average negative earnings surprises of 1.2 percent for the July-September quarter's results.

By the midday break, the Nikkei shed 1.7 percent to 8,621.06 after falling 1.1 percent on Tuesday.

"We have seen a lot of shorts being put out today," a senior dealer at a foreign bank said.

Automakers came under pressure after they confirmed sharp declines in September sales in China after a territorial row between China and Japan sparked boycotts, raising concerns about their future in the world's biggest auto market.

Toyota Motor Corp and Honda Motor Co dropped 1.8 and 1.2 percent, respectively, while auto parts makers also suffered, with Denso Corp, Toyoda Gosei and Exedy Corp down between 3.1 and 3.4 percent.

Shun Maruyama, chief Japan equity strategist at BNP Paribas, said the Nikkei could test 8,500 as short selling by investors were likely to continue in the next one to two weeks.

"Current short selling pressure comes from hedging against the forthcoming results season," Maruyama said.

He said the short-selling ratio on the Nikkei stood at 26 percent on a five-day moving average, below the 28 to 30 percent level when short-covering tends to emerge.

"Eight thousand five hundred is the supporting line for many kinds of options and futures trading. Many investors have 8,500 put options. If the price breaks down below 8,500, ... maybe the market could go down to 8,200, 8,300."

Companies with significant exposure to the PC market came under pressure after Intel Corp, the world's largest semiconductor maker, dropped 2.7 percent following negative reports by at least two brokerages, citing weak demand for notebooks.

A weaker-than-expected third-quarter revenue estimate by U.S. chipmaker Intersil Corp also weighed on the sector.

Ibiden Co Ltd, Shinko Electric Industries Co Ltd, Nidec Corp and TDK Corp were down between 1.9 and 4.4 percent.

TOKYO ELECTRON SURPRISE

But Tokyo Electron Ltd advanced 1.5 percent after its second quarter orders came in at 75 billion yen, above market expectations of between 50 and 60 billion yen, traders said.

The broader Topix index dropped 1.4 percent to 717.64 in relatively active trade, hitting 52 percent of its full daily average for the past 90 days.

According to Thomson Reuters I/B/E/S, Japanese companies are forecast to post an average 57 percent year-on-year rise in earnings in 2012, down from an earlier estimate of 73 percent four months ago. Japanese firms posted a 23 percent year-on-year decline last year, when the country was hit by a massive earthquake and tsunami and suffered the effects of a nuclear meltdown and fallout.

The benchmark Nikkei is up 2 percent so far this year, trailing a 14.6 percent rise in the S&P 500 and a 10.5 percent gain in the pan-European STOXX Europe 600 index.

But Japanese shares are slightly more expensive than their European peers, with a 12-month forward price-to-earnings ratio of 11.4 versus STOXX Europe 600's 11.1, data from Thomson Reuters Datastream showed. The S&P 500's 12-month forward P/E stands at 12.8.

(Editing by Jacqueline Wong)

Source: http://news.yahoo.com/nikkei-hits-2-month-low-corporate-earnings-concerns-032343810--sector.html

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Lloyd's List - Finance - Credit managers reborn

  • Wednesday 10 October 2012, 17:24

WHEN I first arrived at Lloyd?s List Intelligence, then known as MRC, in spring 1997, I was shocked when a very senior analyst implied financial analysis was not that important in this business.Yet this...

Start your complimentary trial today. You are only a few short steps away from experiencing all Lloydslist.com has to offer at no charge

Source: http://www.lloydslist.com/ll/sector/finance/article409207.ece

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Childhood victims of domestic violence recognized in Sandy | The ...

(Chris Detrick | The Salt Lake Tribune) A field of 610 pinwheels outside of Sandy City Hall Tuesday October 9, 2012, represent the 610 children that witnessed domestic violence in Sandy last year. October is National Domestic Violence Awareness month.

Safety ? Physical violence incidents are down, but verbal abuse calls increase last year.

Sandy ? Alisha Lee didn?t see her father hit her mother, but she saw the evidence: broken coffee tables, holes in the wall, and black eyes.

"I still have the memories to this day," said the now 21-year-old. "I don?t think parents always realize the effect on children, and that it sticks with them the rest of their lives."

Her mother left her father when Lee was 7 years old and raised Lee on her own, sometimes working more than one job to support herself and her daughter.

"I?m thankful I have a mother who could take a stand and be strong enough to leave," she said. "It?s so important that we talk about domestic violence, that we?re not ashamed of it."

Lee, who now holds the Miss Legacy beauty contest title and is a student at Utah Valley University, spoke as part of a ceremony in Sandy marking domestic violence awareness month. Officials released 359 purple balloons at city hall Tuesday to symbolize the victims of physical domestic violence in Sandy last year, and also set 610 blue pinwheels in the ground, each symbolizing a child who witnessed that violence.

The pinwheels are meant to serve as a reminder that domestic violence is often a cycle, with children who witness it growing up to repeat it in their own relationships.

"Witnessing domestic violence is a form of child abuse," said Sandy Police Chief Stephen Chapman. "Domestic violence is not just a family issue, it is a crime."

While the number of physically violent domestic incidents dropped by 30 in 2011 from the previous year, the number of verbal-abuse calls increased by 92 last year, to 502.

It isn?t clear whether that rise is a good thing because it signals more people feel comfortable calling the police, or a bad sign because once police arrive, more victims are unwilling or unable to report physical harm, said Barbara Higgins, a family crisis and intervention coordinator for Sandy police.

"That makes us concerned," she said. "Just what is the cause?"

story continues below

City officials are committed to investigating the causes of domestic violence and reducing it, said Mayor Tom Dolan.

"This is not just an exercise to us," he said. "This is a very, very important part of how we treat our citizens and our community."

lwhitehurst@sltrib.com

Twitter: @lwhitehurst

Copyright 2012 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.sltrib.com/sltrib/news/55051652-78/violence-domestic-sandy-lee.html.csp

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Pakistan enraged over attack on teen blogger | WTVR.com ...

By Saeed Ahmed, Nasir Habib and Joe Sterling

ISLAMABAD, Pakistan (CNN) ? The Taliban shooting of 14-year-old Malala Yousufzai for blogging against them was so brazen it commanded the attention of many in a country weary of extremist attacks.

An angry chorus of voices in social media, the street, in newspapers and over the airwaves has decried the attack as cowardly and an example of a government unable to cope with militants.

?I blame the Taliban, first and foremost,? columnist Sami Shah wrote in The Express Tribune, a local English daily. ?I blame the government. All of it.?

Malala was slowly recuperating Wednesday after surgeons worked for three hours to removed a bullet lodged in her neck.

On Tuesday, Taliban militants stopped a van carrying three girls, including Malala, on their way home from school in northwestern Pakistan?s conservative Swat Valley.

One of the gunmen asked which one was Malala Yousufzai. When the girls pointed her out, the men opened fire. The bullets struck all three girls.

For two of them, the injuries were not life-threatening. For Malala, it was touch-and-go for a while.

?We are happy that she survived, but are worried too about her health condition,? said her uncle, Faiz Muhammad, who is with her at a military hospital in Peshawar.

On Wednesday, police took the van driver and the school guard into custody for questioning. They also said they?d identified the culprits.

Meanwhile, the Taliban claimed responsibility for the attack and issued an ominous threat.

?If she survives this time, she won?t next time,? said a spokesman for the Pakistani Taliban. ?We will certainly kill her.?

Mian Iftikhar Hussein, the Khyber-Pakhtunkhwa information minister, said he was declaring a bounty of $100,000 for the capture of the culprits in the attempt on Malala Yousufzai?s life.

Pakistani Army Chief Gen. Ashfaq Parvez Kayani visited Malala in the hospital and delivered a simple message: ?We refuse to bow before terror.? He also noted that the Taliban lack respect for the ?golden words? of the Prophet Mohammed ? ?that the one who is not kind to children is not amongst us.?

?In attacking Malala, the terrorists have failed to grasp that she is not only an individual, but an icon of courage and hope,? the general said.

The chief minister of Punjab said he would bear the cost of Malala?s treatment, calling her ?the daughter of Pakistan.?

The head of PIA, the national airline, said he was putting a plane on standby to take the teenager ?anywhere in the world if needed? for treatment. Two neurosurgeons, one in the United States and one in the United Kingdom, have also offered to fly to Pakistan if needed, the interior minister said.

Throughout the country and around the world, Pakistanis, hurt and angry, prayed.

?Malala is what Taliban will never be,? said Murtaza Haider, the associate dean of research and graduate programs at the Ted Rogers School of Management at Toronto?s Ryerson University, in an opinion piece in the Dawn newspaper.

?She is fearless, enlightened, articulate, and a young Muslim woman who is the face of Pakistan and the hope for a faltering nation that can no longer protect its daughters.?

?If the Taliban wants to fight then they should pick on someone there own size,? a girl said on a local news channel.

Shamila Chaudhary, a former U.S. National Security Council director for Afghanistan and Pakistan, told CNN the incident reverberates among women and girls and even conservative Muslims.

?The Pakistani Taliban don?t have a lot of support in the Pakistani society,? she said. ?They don?t offer social services and justice, they don?t offer any alternative to weak government.?

This latest incident ?makes them more unpopular? among masses of people who view the aspirations of Malala and the Taliban?s resistance to them as a ?fight between good and evil,? said Chaudhary, a senior South Asia fellow at the New America Foundation.

Twitter, the closest thing to a barometer of public opinion, likewise lit up.

?Wasn?t the brute who put a gun to Malala?s little head born to a woman?? wrote Kamran Shafi. ?Did he have sisters, aunts, a wife or four? Bloody filthy terrorist!?

Pakistan?s picturesque Swat Valley was once one of Pakistan?s biggest tourist destinations.

The valley, near the Afghanistan border and about 186 miles (300 km) from the capital city of Islamabad, boasted the country?s only ski resort. It was a draw for trout-fishing enthusiasts and visitors to the ancient Buddhist ruins in the area. But that was before, militants ? their faces covered with dark turbans ? unleashed a wave of violence.

They demanded veils for women, beards for men and a ban on music and television. They allowed boys? schools to operate, but closed those for girls.

It was in this climate that Malala reached out to the outside world through her online blog posts.

She took a stand by writing about her daily battle with extremist militants who used fear and intimidation to force girls to stay at home.

Malala?s online writing led to her being awarded Pakistan?s first National Peace Prize in November.

?I was scared of being beheaded by the Taliban because of my passion for education,? Yousufzai told CNN at the time. ?During their rule, the Taliban used to march into our houses to check whether we were studying or watching television.?

She said that she wanted to be a political leader, that her country ?needs honest and true leaders.?

The Taliban controlled Malala?s valley for years until 2009, when the military cleared it in an operation that also evacuated thousands of families.

But pockets remain, and violence is never far behind.

For Pakistani public officials, Chaudhary said, the incident serves as a reminder of the Taliban?s ends ? keeping girls from going to school and imposing hardline religious and cultural values.

Many are in denial and haven?t accepted ?the extent the Taliban will go to impose their cultural values.?

There have been other examples of violence against women, Chaudhary recalls, including the Taliban flogging of a woman caught on video a few years ago.

That was ?a trigger event ? it pulled a lot of the political elite out of their denial,? she said. ?I see this instance as something similar.?

Chaudhary said there?s a misconception across the world that the political elite sympathize with the Taliban.

That?s untrue, she said. They are scared of them and the possibility of violent retribution against officials and government installations. If the government doesn?t talk about this latest issue and have justice served, it will be a ?step back,? she said.

Sami Shah, the columnist, said the ruling Pakistan People?s Party shares blame.

?There can be a million excuses why the Taliban can still operate with impunity in Pakistan, a lot of them legitimate. But if you are the ruling party, then you must accept responsibility for your failures. And the PPP has resoundingly failed. ?

CNN?s Nasir Habib reported from Islamabad; Saeed Ahmed and Joe Sterling from Atlanta. CNN?s Shaan Khan and Noreen Shams also contributed to this report.

Source: http://wtvr.com/2012/10/10/pakistan-enraged-over-attack-on-teen-blogger/

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